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An SQLite database can be opened or created using the PHP ''sqlite_open()'' function. This function accepts one mandatory and two optional arguments. The first argument is the database name (which, by convention, is given a .sqlite file extension). The second argument specifies option optional UNIX file permission settings. The final argument represents an error message to display if the file cannot be opened.

The ''sqlite_open()'' function returns a database handle on success, or a boolean ''false'' value on failure. A memory resident database can be created by passing in the string '':memory'' as the database file name argument.